Article
Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development.
Molecular and cellular biology - 1 Oct 2006
Rai Kunal, Nadauld Lincoln D, Chidester Stephanie, Manos Elizabeth J, James Smitha R, Karpf Adam R, Cairns Bradley R, Jones David A
Abstract excerpt
DNA methylation and histone methylation are two key epigenetic modifications that help govern heterochromatin dynamics. The roles for these chromatin-modifying activities in directing tissue-specific development remain largely unknown. To address this issue, we examined the roles of DNA methyltransferase 1 (Dnmt1) and the H3K9 histone methyltransferase Suv39h1 in zebra fish development. Knockdown of Dnmt1 in...
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