Article

Epigenetic factors coordinate intestinal development

2018-08-23

Abstract excerpt

Intestinal epithelium development depends on epigenetic modifications, but whether that is also the case for other intestinal tract cell types remains unclear. We found that functional loss of a DNA methylation machinery component, ubiquitin-like protein containing PHD and RING finger domains 1 (uhrf1), leads to reduced enteric neuron number, changes in neuronal morphology, and severe intestinal smooth muscle dis...

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Literature Corpus work: a78791da-2f14-572d-8a89-0ea8cb601900
DOI: 10.1101/399410

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