Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Organ-specific requirements for Hdac1 in liver and pancreas formation.

Developmental biology - 15 Oct 2008

Noël Emily S, Casal-Sueiro Antonio, Busch-Nentwich Elisabeth, Verkade Heather, Dong P Duc Si, Stemple Derek L, Ober Elke A

Abstract excerpt

Liver, pancreas and lung originate from the presumptive foregut in temporal and spatial proximity. This requires precisely orchestrated transcriptional activation and repression of organ-specific gene expression within the same cell. Here, we show distinct roles for the chromatin remodelling factor and transcriptional repressor Histone deacetylase 1 (Hdac1) in endodermal organogenesis in zebrafish. Loss of Hdac1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Zebrafish
Share to Endoderm
Share to Hepatocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylase 1

Share to Histone Deacetylases

Share to Organ Specificity

Share to Pancreas

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 18687323
DOI: 10.1016/j.ydbio.2008.06.040
PMCID: PMC3710974

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Organ-specific requirements for Hdac1 in liver and pancreas formation.PMID 18687323Read ↗

Functional genomics analysis of developing zebrafish and human endoderm reveals highly conserved cis-regulatory modules controlling vertebrate organogenesisSemantic proximity Read ↗

Islet-1 marks the early heart rudiments and is asymmetrically expressed during early rotation of the foregut in the chick embryoSemantic proximity Read ↗

Molecular mechanisms of liver and bile duct developmentSemantic proximity Read ↗

Unique and conserved aspects of gut development in zebrafish.Semantic proximity Read ↗

Cdx4 is required in the endoderm to localize the pancreas and limit beta-cell number.Semantic proximity Read ↗

FGF2 Specifies hESC-Derived Definitive Endoderm into Foregut/Midgut Cell Lineages in a Concentration-Dependent MannerSemantic proximity Read ↗

The Haematopoietically-expressed homeobox transcription factor: roles in development, physiology and diseaseSemantic proximity Read ↗

Defective HNF1A hinders GLI3 processing favoring duodenal versus pancreatic fate, thus leading to intestinal elongation in vivo.Semantic proximity Read ↗

MicroRNA Expression Is Required for Pancreatic Islet Cell Genesis in the MouseSemantic proximity Read ↗

Multiple roles for Med12 in vertebrate endoderm development.Semantic proximity Read ↗

Development of the liver: Insights into organ and tissue morphogenesisSemantic proximity Read ↗

Xenopus pancreas developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.