Article

Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive demethylation in mammals

2018-05-15

Abstract excerpt

Genome-wide DNA demethylation is a unique feature of mammalian development and naïve pluripotent stem cells. So far, it was unclear how mammals specifically achieve global DNA hypomethylation, given the high conservation of the DNA (de-)methylation machinery among vertebrates. We found that DNA demethylation requires TET activity but mostly occurs at sites where TET proteins are not bound suggesting a rather indir...

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Literature Corpus work: bbdfb04e-4221-5d51-9d11-15a0c4ef4f53
DOI: 10.1101/321604

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