Article
Defects in signal transduction caused by a T cell receptor beta chain substitution.
European journal of immunology - 1 Jul 1990
Reno T A, Ley S, Sugiyama E, Cantagrel A, Blumberg R, Bonventre J, Terhorst C, Yeh E T
Abstract excerpt
An antigen-specific T-T hybridoma was mutagenized with ethylmethane sulfonate and negatively selected by anti-Ly-6 antibody-induced growth inhibition. One of the mutants generated, M4/8, had lost surface expression of a T cell receptor (TcR) V beta 8 epitope detected on the surface of the parenta...
Topics
- Antigens, Differentiation, T-Lymphocyte
- Antigens, Ly
- CD3 Complex
- Epitopes
- Ethyl Methanesulfonate
- Hybridomas
- Major Histocompatibility Complex
- Mutation
- Receptors, Antigen, T-Cell
- Receptors, Antigen, T-Cell, alpha-beta
- Receptors, Mitogen
- Signal Transduction
- Structure-Activity Relationship
- T-Lymphocytes