Genetic and mutational analysis of the T-cell antigen receptor.

Abstract excerpt

The studies reviewed here exploit the fact that the TCR is a multisubunit complex whose perturbation initiates an assortment of biochemical pathways and diverse biological responses. The creation and analysis of T cells bearing aberrant TCRs has led to a number of important conclusions and provided a framework for some educated speculation about T-cell biology. The assembly of the TCR is a highly regulated...

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