Article
Genetic and mutational analysis of the T-cell antigen receptor.
Annual review of immunology - 1 Jan 1990
Ashwell J D, Klusner R D
Abstract excerpt
The studies reviewed here exploit the fact that the TCR is a multisubunit complex whose perturbation initiates an assortment of biochemical pathways and diverse biological responses. The creation and analysis of T cells bearing aberrant TCRs has led to a number of important conclusions and provid...
Topics
- Animals
- Humans
- Lymphocyte Activation
- Mutation
- Protein Conformation
- Receptors, Antigen, T-Cell
- T-Lymphocytes