Mutants in signal transduction through the T-cell antigen receptor.

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Article

Mutants in signal transduction through the T-cell antigen receptor.

The Journal of biological chemistry - 15 Mar 1990

Wong J G, Rao A

Abstract excerpt

Mutants of an untransformed helper T-cell clone have been derived by chemical mutagenesis followed by selection for cells incapable of proliferating in response to antigen or anti-CD3. The selection was designed to enrich cells bearing mutations distal to the T-cell antigen receptor. The mutants express normal levels of functional T-cell receptors but are uncoupled from cellular responses, including gene...

Topics

Animals
Antigens
Antigens, CD
Antigens, Differentiation, T-Lymphocyte
CD3 Complex
Cell Line
Clone Cells
Gene Expression
Interleukin-2
Interleukin-3
Ionomycin
Lymphocyte Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

Phosphatidylinositols

Receptors, Antigen, T-Cell

Signal Transduction

T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 2137827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2137827-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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