Article
Effect of the CYP2D6*10 C188T polymorphism on postoperative tramadol analgesia in a Chinese population.
European journal of clinical pharmacology - 1 Nov 2006
Wang GuoXiang, Zhang Hui, He FeiFang, Fang XiangMing
Abstract excerpt
OBJECTIVE: The CYP2D6*10 allele is the most common allele with a frequency ranging from 51.3 to 70% and correlated with a significantly reduced metabolic activity in a Chinese population. The aim of the present study was to investigate whether the CYP2D6*10 allele has an impact on the postoperative analgesia effect of tramadol in Chinese patients recovering from major abdominal surgery. METHODS: A prospective...
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