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Article

Effect of the CYP2D6 gene polymorphism on postoperative analgesia of tramadol in Han nationality nephrectomy patients.

European journal of clinical pharmacology - 1 Jun 2015

Dong Hong, Lu Shu-Jun, Zhang Rui, Liu Dong-Dong, Zhang Yan-Zhuo, Song Chun-Yu

Abstract excerpt

OBJECTIVE: Tramadol is a synthetic opioid which has analgesic efficacy in the postoperative pain. It is metabolized by polymorphic enzyme cytochrome P450 (CYP2D6). Patients with different CYP2D6 genotypes would have different responses to tramadol in pain relief. The CYP2D6*10 allele is the most common allele in a Chinese population. The aim of this study was to evaluate whether the different CYP2D6*10 genotypes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25948472
DOI: 10.1007/s00228-015-1857-4

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