Article

Distribution of CYP2D6 multiplication, CYP2D6*5, and clinical implications in postoperative patients receiving tramadol analgesia in the Minangkabau ethnic group, Indonesia

2025-09-23

Abstract excerpt

<h4>Background: </h4> Cytochrome P450 2D6 (CYP2D6) is an important enzyme that metabolizes commonly used drugs, such as tramadol hydrochloride. Genetic polymorphisms of CYP2D6 have been shown to influence the pharmacodynamic properties of administered drugs. This study aimed to screen postoperative patients (wild-type, CYP2D6*5, and CYP2D6 multiplication) of Minangkabau ethnicity in West Sumatera, Indonesia, who r...

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Literature Corpus work: 7a7e5a2d-4327-5d72-9b1d-23951400be77
DOI: 10.12688/f1000research.155988.3

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