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Article

alpha-Synuclein is colocalized with 14-3-3 and synphilin-1 in A53T transgenic mice.

Acta neuropathologica - 1 Dec 2006

Shirakashi Yoshitomo, Kawamoto Yasuhiro, Tomimoto Hidekazu, Takahashi Ryosuke, Ihara Masafumi

Abstract excerpt

alpha-Synuclein is a major constituent of Lewy bodies, the neuropathological hallmark of Parkinson's disease (PD). Three types of alpha-synuclein mutations, A53T, A30P, and E46K, have been reported in familial PD. Wild-type alpha-synuclein accumulates at high concentrations in Lewy bodies, and this process is accelerated with mutated A53T alpha-synuclein. The accumulation of alpha-synuclein is thought to be...

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PMID: 16957925
DOI: 10.1007/s00401-006-0132-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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