Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Synphilin-1 attenuates neuronal degeneration in the A53T -synuclein transgenic mouse model

25 Feb 2010

Abstract excerpt

Genetic alterations in alpha-synuclein cause autosomal dominant familial Parkinsonism and may contribute to sporadic Parkinson's disease (PD). Synphilin-1 is an alpha-synuclein-interacting protein, with implications in PD pathogenesis related to protein aggregation. Currently, the in vivo role of synphilin-1 in alpha-synuclein-linked pathogenesis is not fully understood. Using the mouse prion protein promoter, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nerve injury and regeneration
Share to Nuclear Receptors and Signaling
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20185556
DOI: 10.1093/hmg/ddq086

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synphilin-1 attenuates neuronal degeneration in the A53T -synuclein transgenic mouse modelPMID 20185556Read ↗

Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.Semantic proximity Read ↗

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.Semantic proximity Read ↗

alpha-Synuclein is colocalized with 14-3-3 and synphilin-1 in A53T transgenic mice.Semantic proximity Read ↗

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice.Semantic proximity Read ↗

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.Semantic proximity Read ↗

Aggregate formation and toxicity by wild-type and R621C synphilin-1 in the nigrostriatal system of mice using adenoviral vectors.Semantic proximity Read ↗

Intranigral injection of Alpha-Synuclein pre-formed fibrils leads to BBB compromise and Bilateral Dopaminergic Neurodegeneration in A53T Alpha-Synuclein transgenic miceSemantic proximity Read ↗

Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation.Semantic proximity Read ↗

Synphilin-1 associates with α-synuclein and promotes the formation of cytosolic inclusionsSemantic proximity Read ↗

Synphilin isoforms and the search for a cellular model of lewy body formation in Parkinson's disease.Semantic proximity Read ↗

SynucleinopathiesSemantic proximity Read ↗

Motor deficits and brain pathology in the Parkinson’s disease mouse model hA53TtgSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.