Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation.

Experimental neurology - 1 Jun 2004

Kotzbauer Paul T, Giasson Benoit I, Kravitz Alexxai V, Golbe Lawrence I, Mark Margery H, Trojanowski John Q, Lee Virginia M-Y

Abstract excerpt

Mutations in the alpha-synuclein (alpha-syn) gene are responsible for a rare familial parkinsonism syndrome, a finding that has led to extensive characterization of altered alpha-syn structure in sporadic Parkinson's disease (PD) and other neurodegenerative disorders. We report here the immunohistochemical, biochemical and ultrastructural characterization of alpha-syn neuropathology in a case of familial PD with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Brain Chemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macromolecular Substances

Share to Neurofibrillary Tangles

Share to Parkinson Disease

Share to Solubility

Share to Synucleins

Share to tau Proteins

Source

Identifiers

PMID: 15144854
DOI: 10.1016/j.expneurol.2004.01.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation.PMID 15144854Read ↗

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.Semantic proximity Read ↗

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice.Semantic proximity Read ↗

Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation.Semantic proximity Read ↗

Synphilin-1 attenuates neuronal degeneration in the A53T -synuclein transgenic mouse modelSemantic proximity Read ↗

The α‐Synucleinopathies: Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System AtrophySemantic proximity Read ↗

The significance of tau and alpha-synuclein inclusions in neurodegenerative diseases.Semantic proximity Read ↗

SynucleinopathiesSemantic proximity Read ↗

Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?Semantic proximity Read ↗

Neuropathology in mice expressing human alpha-synuclein.Semantic proximity Read ↗

Parkinsons Disease and other α-SynucleinopathiesSemantic proximity Read ↗

Human Wild-Type α-Synuclein Drives Progressive Tau Pathology in a Disease-Relevant Mouse Model of SynucleinopathySemantic proximity Read ↗

Loss of Tau Expression Attenuates Neurodegeneration Associated With α-SynucleinopathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.