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Article

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 4 Jan 2006

Martin Lee J, Pan Yan, Price Ann C, Sterling Wanda, Copeland Neal G, Jenkins Nancy A, Price Donald L, Lee Michael K

Abstract excerpt

Alpha-synuclein (alpha-Syn) is enriched in nerve terminals. Two mutations in the alpha-Syn gene (Ala53--> Thr and Ala30--> Pro) occur in autosomal dominant familial Parkinson's disease. Mice overexpressing the human A53T mutant alpha-Syn develop a severe movement disorder, paralysis, and synucleinopathy, but the mechanisms are not understood. We examined whether transgenic mice expressing human wild-type or...

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Identifiers

PMID: 16399671
DOI: 10.1523/JNEUROSCI.4308-05.2006
PMCID: PMC6381830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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