Article
Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America - 25 Jun 2002
Lee Michael K, Stirling Wanda, Xu Yanqun, Xu Xueying, Qui Dike, Mandir Allen S, Dawson Ted M, Copeland Neal G, Jenkins Nancy A, Price Don L
Abstract excerpt
Mutations in alpha-synuclein (alpha-Syn) cause Parkinson's disease (PD) in a small number of pedigrees with familial PD. Moreover, alpha-Syn accumulates as a major component of Lewy bodies and Lewy neurites, intraneuronal inclusions that are neuropathological hallmarks of PD. To better understand the pathogenic relationship between alterations in the biology of alpha-Syn and PD-associated neurodegeneration, we...
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