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Article

Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation.

Molecular and cellular neurosciences - 1 Oct 2003

Gispert Suzana, Del Turco Domenico, Garrett Lisa, Chen Amy, Bernard David J, Hamm-Clement John, Korf Horst-Werner, Deller Thomas, Braak Heiko, Auburger Georg, Nussbaum Robert L

Abstract excerpt

Alpha-synuclein was implicated in Parkinson's disease when missense mutations in the alpha-synuclein gene were found in autosomal dominant Parkinson's disease and alpha-synuclein was shown to be a major constituent of protein aggregates in sporadic Parkinson's disease and other synucleinopathies. We have generated transgenic mice expressing A53T mutant and wild-type human alpha-synuclein. The mutant transgenic...

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PMID: 14572463
DOI: 10.1016/s1044-7431(03)00198-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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