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Article

Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.

Human molecular genetics - 1 Feb 2014

Casadei Nicolas, Pöhler Anne-Maria, Tomás-Zapico Cristina, Torres-Peraza Jesús, Schwedhelm Ivo, Witz Annemarie, Zamolo Irina, De Heer Raymond, Spruijt Berry, Noldus Lucas P J J, Klucken Jochen, Lucas José J, Kahle Philipp J, Krüger Rejko, Riess Olaf, Nuber Silke

Abstract excerpt

Lewy bodies and neurites are the pathological hallmark of Parkinson's disease. These structures are composed of fibrillized and ubiquitinated alpha-synuclein suggesting that impaired protein clearance is an important event in aggregate formation. The A30P mutation is known for its fast oligomeriz...

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PMID: 24064336
DOI: 10.1093/hmg/ddt467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24064336-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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