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Article

Neuropathology in mice expressing human alpha-synuclein.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Aug 2000

van der Putten H, Wiederhold K H, Probst A, Barbieri S, Mistl C, Danner S, Kauffmann S, Hofele K, Spooren W P, Ruegg M A, Lin S, Caroni P, Sommer B, Tolnay M, Bilbe G

Abstract excerpt

The presynaptic protein alpha-synuclein is a prime suspect for contributing to Lewy pathology and clinical aspects of diseases, including Parkinson's disease, dementia with Lewy bodies, and a Lewy body variant of Alzheimer's disease. alpha-Synuclein accumulates in Lewy bodies and Lewy neurites, and two missense mutations (A53T and A30P) in the alpha-synuclein gene are genetically linked to rare familial forms of...

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Identifiers

PMID: 10934251
PMCID: PMC6772584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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