Article
Neuropathology in mice expressing human alpha-synuclein.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Aug 2000
van der Putten H, Wiederhold K H, Probst A, Barbieri S, Mistl C, Danner S, Kauffmann S, Hofele K, Spooren W P, Ruegg M A, Lin S, Caroni P, Sommer B, Tolnay M, Bilbe G
Abstract excerpt
The presynaptic protein alpha-synuclein is a prime suspect for contributing to Lewy pathology and clinical aspects of diseases, including Parkinson's disease, dementia with Lewy bodies, and a Lewy body variant of Alzheimer's disease. alpha-Synuclein accumulates in Lewy bodies and Lewy neurites, and two missense mutations (A53T and A30P) in the alpha-synuclein gene are genetically linked to rare familial forms of...
Topics
- Animals
- Central Nervous System
- Gene Expression Regulation
- Humans
- Lewy Bodies
- Mice
- Mice, Transgenic
- Motor Activity
- Motor Neurons
- Movement Disorders
- Mutation
- Nerve Degeneration
- Nerve Tissue Proteins