Article

Templating of Monomeric Alpha-Synuclein Induces Inflammation and SNpc Dopamine Neuron Death in a Genetic Mouse Model of Synucleinopathy

2024-07-30

Abstract excerpt

While the etiology of most cases of Parkinson’s disease (PD) are idiopathic, it has been estimated that 5-10% of PD arise from known genetic mutations. The first mutations described that leads to the development of an autosomal dominant form of PD are in the SNCA gene that codes for the protein alpha-synuclein (α-syn). α-syn is an abundant presynaptic protein that is natively disordered and whose function is still...

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Literature Corpus work: 285fed14-adaf-5078-9dd6-85e23ec604cb
DOI: 10.1101/2024.07.29.605647

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