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Article

Akt phosphorylation is essential for nuclear translocation and retention in NGF-stimulated PC12 cells.

Biochemical and biophysical research communications - 20 Oct 2006

Xuan Nguyen Truong Le, Choi Joung Woo, Lee Sang Bae, Ye Keqiang, Woo Soo-Dong, Lee Kyung-Hoon, Ahn Jee-Yin

Abstract excerpt

Nerve growth factor (NGF) elicits Akt translocation into the nucleus, where it phosphorylates nuclear targets. Here, we describe that Akt phosphorylation can promote the nuclear translocation of Akt and is necessary for its nuclear retention. Overexpression of Akt-K179A, T308A, S473A-mutant faile...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16956580
DOI: 10.1016/j.bbrc.2006.08.120

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16956580-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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