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Article

Hsp70/Hsc70 regulates the effect phosphorylation has on stabilizing ataxin-1.

Journal of neurochemistry - 1 Sept 2007

Jorgensen Nathan D, Andresen J Michael, Pitt Jason E, Swenson Melissa A, Zoghbi Huda Y, Orr Harry T

Abstract excerpt

Spinocerebellar ataxia type 1 (SCA1) is an inherited neurodegenerative disorder. The mutation causing SCA1 is an expansion in the polyglutamine tract of the ATXN1 protein. Previous work demonstrated that phosphorylation of mutant ATXN1 at serine 776 (S776), a putative Akt phosphorylation site, is critical for pathogenesis. To examine this pathway further, we utilized a cell-transfection system that allowed the...

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Source

Identifiers

PMID: 17540008
DOI: 10.1111/j.1471-4159.2007.04678.x

Genes

ATXN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hsp70/Hsc70 regulates the effect phosphorylation has on stabilizing ataxin-1.PMID 17540008Read ↗

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