Article
Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha.
The Biochemical journal - 1 May 2006
Srinivas Harish, Xia Dianren, Moore Nicole L, Uray Ivan P, Kim Heetae, Ma Long, Weigel Nancy L, Brown Powel H, Kurie Jonathan M
Abstract excerpt
The transactivation of nuclear receptors is regulated by both ligand binding and phosphorylation. We previously showed that RARalpha (retinoic acid receptor alpha) phosphorylation by c-Jun N-terminal kinase contributes to retinoid resistance in a subset of NSCLC cells (non-small cell lung cancer cells), but the aetiology of this resistance in the remainder has not been fully elucidated [Srinivas, Juroske,...
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