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Article

Rab7 mutants associated with Charcot-Marie-Tooth disease exhibit enhanced NGF-stimulated signaling.

PloS one - 9 Dec 2010

BasuRay Soumik, Mukherjee Sanchita, Romero Elsa, Wilson Michael C, Wandinger-Ness Angela

Abstract excerpt

Missense mutants in the late endosomal Rab7 GTPase cause the autosomal dominant peripheral neuropathy Charcot-Marie-Tooth disease type 2B (CMT2B). As yet, the pathological mechanisms connecting mutant Rab7 protein expression to altered neuronal function are undefined. Here, we analyze the effects Rab7 CMT2B mutants on nerve growth factor (NGF) dependent intracellular signaling in PC12 cells. The nerve growth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21151572
DOI: 10.1371/journal.pone.0015351
PMCID: PMC3000344

Genes

NGF

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