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Article

Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation.

The EMBO journal - 19 Oct 2005

Hu Yuanxin, Yao Joyce, Liu Zhixue, Liu Xia, Fu Haian, Ye Keqiang

Abstract excerpt

Akt promotes cell survival by phosphorylating and inhibiting components of the intrinsic cell death machinery. Akt translocates into the nucleus upon exposure of cells to survival factors, but little is known about its functions in the nucleus. Here, we show that acinus, a nuclear factor required for apoptotic chromatin condensation, is a direct target of Akt. We demonstrate that Akt phosphorylation of acinus on...

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Identifiers

PMID: 16177823
DOI: 10.1038/sj.emboj.7600823
PMCID: PMC1276706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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