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Article

Akt phosphorylation at Thr308 and Ser473 is required for CHIP-mediated ubiquitination of the kinase.

Cellular signalling - 1 Nov 2011

Su Chih-Hao, Wang Cheng-Yi, Lan Keng-Hsin, Li Chung-Pin, Chao Yee, Lin Han-Chieh, Lee Shou-Dong, Lee Wei-Ping

Abstract excerpt

Phosphorylation at Thr308 and Ser473 is known to activate Akt, a major kinase in mammalian cells. Once activated to turn on downstream signaling pathways, Akt returns to an inactive pool via PP2A-mediated dephosphorylation. We show here that Thr308 and Ser473 phosphorylations prompt Akt to enter...

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Identifiers

PMID: 21767636
DOI: 10.1016/j.cellsig.2011.06.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21767636-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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