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Article

Stress-related negative affectivity and genetically altered serotonin transporter function: evidence of synergism in shaping risk of depression.

Archives of general psychiatry - 1 Sept 2006

Jacobs Nele, Kenis Gunter, Peeters Frenk, Derom Catherine, Vlietinck Robert, van Os Jim

Abstract excerpt

CONTEXT: Genetic moderation of the depression-inducing effects of stressful life events (SLEs) has been reported, but findings suggest that genes may not moderate the effects of SLEs per se but instead may moderate the risk of depression associated with the stable tendency to develop negative emotions in response to minor environmental experiences. OBJECTIVE: To examine whether a functional polymorphism of the...

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PMID: 16953001
DOI: 10.1001/archpsyc.63.9.989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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