Variations in 5-HTTLPR: relation to familiar risk of affective disorder, life events, neuroticism and cortisol.

doi:10.1016/j.pnpbp.2009.10.002

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Article

Variations in 5-HTTLPR: relation to familiar risk of affective disorder, life events, neuroticism and cortisol.

Progress in neuro-psychopharmacology & biological psychiatry - 1 Feb 2010

Vinberg Maj, Mellerup Erling, Andersen Per Kragh, Bennike Bente, Kessing Lars Vedel

Abstract excerpt

BACKGROUND: Variations in the serotonin transporter gene (5-HTTLPR) and stressful life events are associated with affective disorders. AIM: To investigate whether the distribution of the alleles of the 5-HTTLPR is associated with a genetic predisposition to affective disorder and whether these variations interact with life events in relation to depressive symptoms, neuroticism and salivary cortisol. METHOD: In a...

Topics

Adult
Diseases in Twins
Family Health
Female
Genetic Predisposition to Disease
Humans
Hydrocortisone
Life Change Events
Male
Middle Aged
Mood Disorders
Multivariate Analysis
Neurotic Disorders
Polymorphism, Genetic

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Open in PubMed

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PMID: 19822181
DOI: 10.1016/j.pnpbp.2009.10.002

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Serotonin Plasma Membrane Transport Proteins