Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication.

Archives of general psychiatry - 1 May 2005

Kendler Kenneth S, Kuhn Jonathan W, Vittum Jen, Prescott Carol A, Riley Brien

Abstract excerpt

CONTEXT: Prior evidence from twin studies suggested genetic moderation of the depressogenic effects of stressful life events (SLEs). Can the specific genes involved in this effect be identified? OBJECTIVE: To replicate and extend a recent study that a functional variant in the serotonin transporter (5-HTT) might in part explain these findings. DESIGN: Characterizing risk for major depression and generalized...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anxiety Disorders
Share to Depressive Disorder, Major

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diseases in Twins

Share to Life Change Events

Share to Membrane Transport Proteins

Share to Serotonin Plasma Membrane Transport Proteins

Share to Twins, Dizygotic

Share to Twins, Monozygotic

Source

Identifiers

PMID: 15867106
DOI: 10.1001/archpsyc.62.5.529

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication.PMID 15867106Read ↗

Stressful life events and the serotonin transporter gene (5-HTT) in recurrent clinical depression.Semantic proximity Read ↗

Depression, Stressful Life Events, and the Impact of Variation in the Serotonin Transporter: Findings from the National Longitudinal Study of Adolescent to Adult Health (Add Health).Semantic proximity Read ↗

The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression.Semantic proximity Read ↗

Stress-related negative affectivity and genetically altered serotonin transporter function: evidence of synergism in shaping risk of depression.Semantic proximity Read ↗

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.Semantic proximity Read ↗

Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis.Semantic proximity Read ↗

Life stress, 5-HTTLPR and mental disorder: findings from a 30-year longitudinal study.Semantic proximity Read ↗

Serotonin transporter gene polymorphism (5-HTTLPR) and anxiety reactivity in daily life: a daily process approach to gene-environment interaction.Semantic proximity Read ↗

Serotonin transporter genotype, salivary cortisol, neuroticism and life events: impact on subsequent psychopathology in healthy twins at high and low risk for affective disorder.Semantic proximity Read ↗

Serotonin transporter gene as a predictor of stress generation in depression.Semantic proximity Read ↗

Interaction between genetic polymorphisms and stressful life events in first episode depression.Semantic proximity Read ↗

Variations in 5-HTTLPR: relation to familiar risk of affective disorder, life events, neuroticism and cortisol.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.