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Article

Additive genetic risk from five serotonin system polymorphisms interacts with interpersonal stress to predict depression.

Journal of abnormal psychology - 1 Nov 2015

Vrshek-Schallhorn Suzanne, Stroud Catherine B, Mineka Susan, Zinbarg Richard E, Adam Emma K, Redei Eva E, Hammen Constance, Craske Michelle G

Abstract excerpt

Behavioral genetic research supports polygenic models of depression in which many genetic variations each contribute a small amount of risk, and prevailing diathesis-stress models suggest gene-environment interactions (G×E). Multilocus profile scores of additive risk offer an approach that is consistent with polygenic models of depression risk. In a first demonstration of this approach in a G×E predicting...

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Share to Depressive Disorder, Major
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Serotonin

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Source

Open in PubMed Open full text

Identifiers

PMID: 26595467
DOI: 10.1037/abn0000098
PMCID: PMC4948188

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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