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Article

Gata3 participates in a complex transcriptional feedback network to regulate sympathoadrenal differentiation.

Development (Cambridge, England) - 1 Oct 2006

Moriguchi Takashi, Takako Nakano, Hamada Michito, Maeda Atsuko, Fujioka Yuki, Kuroha Takashi, Huber Reuben E, Hasegawa Susan L, Rao Arvind, Yamamoto Masayuki, Takahashi Satoru, Lim Kim-Chew, Engel James Douglas

Abstract excerpt

Gata3 mutant mice expire of noradrenergic deficiency by embryonic day (E) 11 and can be rescued pharmacologically or, as shown here, by restoring Gata3 function specifically in sympathoadrenal (SA) lineages using the human DBH promoter to direct Gata3 transgenic expression. In Gata3-null embryos, there was significant impairment of SA differentiation and increased apoptosis in adrenal chromaffin cells and...

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Share to Adrenal Medulla
Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Embryo, Mammalian

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Share to Ganglia, Sympathetic

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Source

Identifiers

PMID: 16943277
DOI: 10.1242/dev.02553

Genes

DBH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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