Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Essential role of Gata transcription factors in sympathetic neuron development.

Development (Cambridge, England) - 1 Oct 2004

Tsarovina Konstantina, Pattyn Alexandre, Stubbusch Jutta, Müller Frank, van der Wees Jacqueline, Schneider Carolin, Brunet Jean-Francois, Rohrer Hermann

Abstract excerpt

Sympathetic neurons are specified during their development from neural crest precursors by a network of crossregulatory transcription factors, which includes Mash1, Phox2b, Hand2 and Phox2a. Here, we have studied the function of Gata2 and Gata3 zinc-finger transcription factors in autonomic neuron development. In the chick, Gata2 but not Gata3 is expressed in developing sympathetic precursor cells. Gata2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to Bone Morphogenetic Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chick Embryo

Share to GATA2 Transcription Factor

Share to GATA3 Transcription Factor

Share to Norepinephrine

Share to Sympathetic Nervous System

Share to Zebrafish Proteins

Source

Identifiers

PMID: 15329349
DOI: 10.1242/dev.01370

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Essential role of Gata transcription factors in sympathetic neuron development.PMID 15329349Read ↗

Gata3 participates in a complex transcriptional feedback network to regulate sympathoadrenal differentiation.Semantic proximity Read ↗

Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system.Semantic proximity Read ↗

The Gata3 transcription factor is required for the survival of embryonic and adult sympathetic neurons.Semantic proximity Read ↗

MASH1 activates expression of the paired homeodomain transcription factor Phox2a, and couples pan-neuronal and subtype-specific components of autonomic neuronal identity.Semantic proximity Read ↗

Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system.Semantic proximity Read ↗

Differential regulation of transcription factor gene expression and phenotypic markers in developing sympathetic neurons.Semantic proximity Read ↗

The emerging role of GATA transcription factors in development and disease.Semantic proximity Read ↗

Cardiac Neural Crest Expression of Hand2 Regulates Outflow and Second Heart Field DevelopmentSemantic proximity Read ↗

Distinct neuroblastoma-associated alterations of PHOX2B impair sympathetic neuronal differentiation in zebrafish models.Semantic proximity Read ↗

Msx2 is an immediate downstream effector of Pax3 in the development of the murine cardiac neural crest.Semantic proximity Read ↗

Neuroblastoma phox2b variants stimulate proliferation and dedifferentiation of immature sympathetic neurons.Semantic proximity Read ↗

Specification of the central noradrenergic phenotype by the homeobox gene Phox2b.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.