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Article

Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system.

Developmental biology - 1 Jul 2007

Morikawa Yuka, D'Autréaux Fabien, Gershon Michael D, Cserjesi Peter

Abstract excerpt

The basic helix-loop-helix (bHLH) transcription factor Hand2 has been shown to play a role in the development of the mammalian sympathetic nervous system (SNS); however, its precise role could not be uncovered because Hand2 is required for early embryonic survival. We therefore generated a conditional Hand2 knockout mouse line by excising Hand2 in Wnt1-Cre-expressing neural crest-derived cells. These mice die at...

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Source

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Identifiers

PMID: 17531968
DOI: 10.1016/j.ydbio.2007.04.027
PMCID: PMC1952239

Genes

DBH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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