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Article

Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system.

Developmental biology - 1 Jul 2007

Morikawa Yuka, D'Autréaux Fabien, Gershon Michael D, Cserjesi Peter

Abstract excerpt

The basic helix-loop-helix (bHLH) transcription factor Hand2 has been shown to play a role in the development of the mammalian sympathetic nervous system (SNS); however, its precise role could not be uncovered because Hand2 is required for early embryonic survival. We therefore generated a conditional Hand2 knockout mouse line by excising Hand2 in Wnt1-Cre-expressing neural crest-derived cells. These mice die at...

Topics

Animals
Basic Helix-Loop-Helix Transcription Factors
Catecholamines
Cell Differentiation
Cell Proliferation
Embryo, Mammalian
Mice
Mice, Knockout
Neural Crest
Neurons
Norepinephrine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Sympathetic Nervous System

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 17531968
DOI: 10.1016/j.ydbio.2007.04.027
PMCID: PMC1952239

Genes

DBH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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