Article
Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis.
Nature genetics - 1 Sept 1995
Pandolfi P P, Roth M E, Karis A, Leonard M W, Dzierzak E, Grosveld F G, Engel J D, Lindenbaum M H
Abstract excerpt
GATA-3 is one member of a growing family of related transcription factors which share a strongly conserved expression pattern in all vertebrate organisms. In order to elucidate GATA-3 function using a direct genetic approach, we have disrupted the murine gene by homologous recombination in embryo...
Topics
- Abnormalities, Multiple
- Animals
- Cells, Cultured
- Craniofacial Dysostosis
- DNA-Binding Proteins
- Embryo, Mammalian
- Fetal Death
- GATA2 Transcription Factor
- GATA3 Transcription Factor
- Gene Expression Regulation, Developmental
- Gene Targeting