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Article

Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system.

Nature genetics - 1 Jun 2000

Lim K C, Lakshmanan G, Crawford S E, Gu Y, Grosveld F, Engel J D

Abstract excerpt

Mouse embryos deficient in Gata3 die by 11 days post coitum (d.p.c.) from pathology of undetermined origin. We recently showed that Gata3-directed lacZ expression of a 625-kb Gata3 YAC transgene in mice mimics endogenous Gata3 expression, except in thymus and the sympathoadrenal system. As this transgene failed to overcome embryonic lethality (unpublished data and ref. 3) in Gata3-/- mice, we hypothesized that a...

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PMID: 10835639
DOI: 10.1038/76080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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