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Article

The Gata3 transcription factor is required for the survival of embryonic and adult sympathetic neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 Aug 2010

Tsarovina Konstantina, Reiff Tobias, Stubbusch Jutta, Kurek Dorota, Grosveld Frank G, Parlato Rosanna, Schütz Günther, Rohrer Hermann

Abstract excerpt

The transcription factor Gata3 is essential for the development of sympathetic neurons and adrenal chromaffin cells. As Gata3 expression is maintained up to the adult stage, we addressed its function in differentiated sympathoadrenal cells at embryonic and adult stages by conditional Gata3 elimination. Inactivation of Gata3 in embryonic DBH-expressing neurons elicits a strong reduction in neuron numbers due to...

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Source

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Identifiers

PMID: 20702712
DOI: 10.1523/JNEUROSCI.0175-10.2010
PMCID: PMC6634692

Genes

DBH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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