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Article

C. elegans FANCD2 responds to replication stress and functions in interstrand cross-link repair.

DNA repair - 8 Nov 2006

Collis Spencer J, Barber Louise J, Ward Jordan D, Martin Julie S, Boulton Simon J

Abstract excerpt

One of the least well understood DNA repair processes in cells is the repair of DNA interstrand cross-links (ICLs) which present a major obstacle to DNA replication and must be repaired or bypassed to allow fork progression. Fanconi anemia (FA) is an inherited genome instability syndrome characterized by hypersensitivity to ICL damage. Central to the FA repair pathway is FANCD2 that is mono-ubiquitylated in...

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Source

Identifiers

PMID: 16914393
DOI: 10.1016/j.dnarep.2006.06.010

Genes

FANCD2
FANCL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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C. elegans FANCD2 responds to replication stress and functions in interstrand cross-link repair.PMID 16914393Read ↗

FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response.Semantic proximity Read ↗

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The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link RepairSemantic proximity Read ↗

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Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans.Semantic proximity Read ↗

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Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability.Semantic proximity Read ↗

Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights.Semantic proximity Read ↗

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Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage.Semantic proximity Read ↗

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