Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability.

Science (New York, N.Y.) - 19 Feb 2016

Lachaud Christophe, Moreno Alberto, Marchesi Francesco, Toth Rachel, Blow J Julian, Rouse John

Abstract excerpt

Mono-ubiquitination of Fancd2 is essential for repairing DNA interstrand cross-links (ICLs), but the underlying mechanisms are unclear. The Fan1 nuclease, also required for ICL repair, is recruited to ICLs by ubiquitinated (Ub) Fancd2. This could in principle explain how Ub-Fancd2 promotes ICL repair, but we show that recruitment of Fan1 by Ub-Fancd2 is dispensable for ICL repair. Instead, Fan1 recruitment--and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endodeoxyribonucleases
Share to Exodeoxyribonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fanconi Anemia Complementation Group D2 Protein

Share to Gene Knock-In Techniques

Share to Genomic Instability

Share to Lymphoma

Share to Multifunctional Enzymes

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 26797144
DOI: 10.1126/science.aad5634
PMCID: PMC4770513

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability.PMID 26797144Read ↗

SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells.Semantic proximity Read ↗

Fanconi anaemia and cancer: an intricate relationship.Semantic proximity Read ↗

Expanded roles of the Fanconi anemia pathway in preserving genomic stability.Semantic proximity Read ↗

FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response.Semantic proximity Read ↗

Nuclease delivery: versatile functions of SLX4/FANCP in genome maintenance.Semantic proximity Read ↗

A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.Semantic proximity Read ↗

Regulation of the Fanconi anemia pathway by a CUE ubiquitin-binding domain in the FANCD2 protein.Semantic proximity Read ↗

The Fanconi Anemia Pathway of Genomic MaintenanceSemantic proximity Read ↗

Exploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer TherapySemantic proximity Read ↗

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.Semantic proximity Read ↗

Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility.Semantic proximity Read ↗

C. elegans FANCD2 responds to replication stress and functions in interstrand cross-link repair.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.