Article
In vitro differentiation and proliferation of purified human thymic and bone marrow CD7+CD2- T-cell precursors.
Experimental hematology - 1 May 1990
Mossalayi M D, Dalloul A H, Bertho J M, Lecron J C, Goube de Laforest P G, Debré P
Abstract excerpt
It is well established that CD7, gp40 antigen is one of the first antigens detected on the surfaces of cells of the human T-cell lineage. Using complement-dependent cytotoxicity and immunoadherence to anti-CD7-coated surfaces, we were able to purify CD7+2-3-4-8-TcR- cells with greater than 90% purity from both human thymus and bone marrow. Limiting dilution analysis showed that these cells displayed high ability...
Topics
- Antigens, CD
- Antigens, CD7
- Antigens, Differentiation, T-Lymphocyte
- Bone Marrow Cells
- CD2 Antigens
- Cell Differentiation
- Cell Division
- Child, Preschool
- Humans
- Lymphokines
- Phenotype