Article
Identification of a novel human thymocyte subset with a phenotype of CD3- CD4+ CD8 alpha + beta-1. Possible progeny of the CD3- CD4- CD8- subset.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1991
Hori T, Cupp J, Wrighton N, Lee F, Spits H
Abstract excerpt
We investigated responsiveness to cytokines and differentiating potential of early human T cell precursors in vitro. Human CD3- CD4- CD8- (triple negative) thymocytes were highly purified by using magnetic bead columns and cell sorting. These cells proliferated for the first 3 to 4 days and then...
Topics
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- CD3 Complex
- CD4 Antigens
- CD8 Antigens
- Cells, Cultured
- Hematopoietic Stem Cells
- Humans
- Interleukin-2
- Interleukin-4
- Interleukin-7
- Lymphocyte Activation
- Phenotype
- Receptors, Antigen, T-Cell
- T-Lymphocyte Subsets