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Article

CD80, CD86 and CD40 Provide Accessory Signals in a Multiple‐Step T‐Cell Activation Model

1 Oct 1996

Abstract excerpt

In this review, a sequential multiple-step model for T-cell activation is proposed. In a series of in vitro studies, highly purified freshly isolated human peripheral blood T lymphocytes were stimulated through the CD28 receptor, with mAb or with natural ligands B7-1 or B7-2, along with TCR stimulation, in the absence of other costimulatory interactions. Ligation of the CD28 receptor, along with stimulation of...

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Identifiers

PMID: 9010719
DOI: 10.1111/j.1600-065x.1996.tb00920.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD80, CD86 and CD40 Provide Accessory Signals in a Multiple‐Step T‐Cell Activation ModelPMID 9010719Read ↗

Integration of CD28 and CTLA-4 function results in differential responses of T cells to CD80 and CD86.Semantic proximity Read ↗

Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunitySemantic proximity Read ↗

CD8+ CD28− and CD8+ CD57+ T cells and their role in health and diseaseSemantic proximity Read ↗

Response differences between human CD4(+) and CD8(+) T-cells during CD28 costimulation: implications for immune cell-based therapies and studies related to the expansion of double-positive T-cells during aging.Semantic proximity Read ↗

The story of CD4+ CD28- T cells revisited: solved or still ongoing?Semantic proximity Read ↗

Molecular insights into T cell development, activation and signal transduction (Review)Semantic proximity Read ↗

The B7 family of immune-regulatory ligands.Semantic proximity Read ↗

The Role of the CD28 Family Receptors in T-Cell ImmunomodulationSemantic proximity Read ↗

Yin–Yang of costimulation: crucial controls of immune tolerance and functionSemantic proximity Read ↗

Studies Using Antigen-Presenting Cells Lacking Expression of Both B7-1 (CD80) and B7-2 (CD86) Show Distinct Requirements for B7 Molecules During Priming Versus Restimulation of Th2 But Not Th1 Cytokine ProductionSemantic proximity Read ↗

Considering B7-CD28 as a family through sequence and structureSemantic proximity Read ↗

The third group of the B7‐ CD 28 immune checkpoint family: HHLA 2, TMIGD 2, B7x, and B7‐H3Semantic proximity Read ↗

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