Article
[Phenotypic and functional characterization of human prothymocytes].
Comptes rendus des seances de la Societe de biologie et de ses filiales - 1 Jan 1994
Mossalayi M D, Dalloul A H, Blanc C, Arock M, Debré P
Abstract excerpt
We report herein the phenotypic and functional analysis of human bone marrow and thymus derived early T cells. Commitment to T cell lineage is acquired during CD7 antigen expression by CD34+ precursors in human bone marrow and before thymus colonization. Early thymocytes show similar phenotypic characteristics as bone marrow T cells. They rapidly acquire CD4 before the dual expression of CD4 and CD8. Their...
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