Exogenous IL-7 promotes the growth of CD3-CD4-CD8-CD44+CD25+/- precursor cells and blocks the differentiation pathway of TCR-alpha beta cells in fetal thymus organ culture.

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Article

Exogenous IL-7 promotes the growth of CD3-CD4-CD8-CD44+CD25+/- precursor cells and blocks the differentiation pathway of TCR-alpha beta cells in fetal thymus organ culture.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 1993

Plum J, De Smedt M, Leclercq G

Abstract excerpt

Addition of human rIL-7 to fetal thymic organ culture started at day 13, 14, or 15 did not influence the number of cells generated during a 12-day culture period. However, the IL-7 treatment resulted in a preferential expansion of cells with a phenotype characteristic for cells at an early step of differentiation. The cells were CD4-CD8-CD3-CD2- and SCA-1+. Analysis of the coordinate expression of CD44 and CD25...

Topics

Animals
Antigens, CD
Antigens, Differentiation, T-Lymphocyte
Antigens, Ly
CD2 Antigens
CD3 Complex
CD4 Antigens
CD8 Antigens
Cell Differentiation
Cell Division
Cell Size

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fetus

Hematopoietic Stem Cells

Interleukin-7

Leukocyte Count

Membrane Proteins

Mice

Mice, Inbred BALB C

Source

Open in PubMed

Identifiers

PMID: 8095954

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8095954-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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