Article
Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7- lympho-myeloid thymic progenitors.
Blood - 1 Feb 2008
Hao Qian-Lin, George Aswathi A, Zhu Judy, Barsky Lora, Zielinska Ewa, Wang Xiuli, Price Mary, Ge Shundi, Crooks Gay M
Abstract excerpt
The identity and lineage potential of the cells that initiate thymopoiesis remain controversial. The goal of these studies was to determine, at a clonal level, the immunophenotype and differentiation pathways of the earliest progenitors in human thymus. Although the majority of human CD34(+)lin(-) thymocytes express high levels of CD7, closer analysis reveals that a continuum of CD7 expression exists, and 1% to...
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