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Article

TCR-independent activation of human CD4+ 45RO- T cells by anti-CD28 plus IL-2: Induction of clonal expansion and priming for a Th2 phenotype.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 1996

Brinkmann V, Kinzel B, Kristofic C

Abstract excerpt

In this study we show that uncommitted human CD4+ CD45RA+ RO- CD25- CD71- HLA-DR- T cells can be primed for a Th2 phenotype before they encounter TCR signals and before they are exposed to IL-4. We found that >99% of uncommitted T cells proliferated upon costimulation by immobilized anti-CD3 plus...

Topics

Antibodies, Monoclonal
CD28 Antigens
CD4-Positive T-Lymphocytes
Cell Differentiation
Clone Cells
Humans
In Vitro Techniques
Interleukin-2
Interleukin-4
Leukocyte Common Antigens
Lymphocyte Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Receptors, Antigen, T-Cell

Signal Transduction

Stem Cells

Th2 Cells

Source

Identifiers

PMID: 8666775

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8666775-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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