Article
Normal human bone marrow precursors that express terminal deoxynucleotidyl transferase include T-cell precursors and possible lymphoid stem cells.
Blood - 15 Apr 1991
Gore S D, Kastan M B, Civin C I
Abstract excerpt
To compare the differentiation of early B- and T-lymphoid precursors, we have used immune adherence combined with analytical flow cytometric techniques to enrich and characterize subsets of the small population of bone marrow mononuclear cells that express the enzyme terminal deoxynucleotidyl transferase (TdT) but lack the CD19 B-lymphoid marker. Two percent to five percent of bone marrow TdT + mononuclear cells...
Topics
- Adult
- Antigens, CD
- Bone Marrow
- Bone Marrow Cells
- Cell Adhesion
- Cell Differentiation
- DNA Nucleotidylexotransferase
- Flow Cytometry
- Fluorescent Antibody Technique
- HLA-DR Antigens
- Hematopoietic Stem Cells