Article
Immunohistochemical analysis of ZAP-70 expression in B-cell lymphoid neoplasms.
The Journal of pathology - 1 Mar 2005
Carreras Joaquim, Villamor Neus, Colomo Lluís, Moreno Carol, Ramón y Cajal Santiago, Crespo Marta, Tort Frederic, Bosch Francesc, López-Guillermo Armando, Colomer Dolors, Montserrat Emili, Campo Elías
Abstract excerpt
ZAP-70 is a tyrosine kinase that participates in early B-cell differentiation and is a prognostic factor in chronic lymphocytic leukaemia (CLL), where it is associated with an unmutated configuration of the IgV(H) genes. In this study ZAP-70 expression was studied by immunohistochemistry in a spectrum of B-cell lymphoid neoplasms; this staining method was compared with flow cytometry, and the relationship of...
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