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Article

Genetic inactivation of the APC gene contributes to the malignant progression of sporadic hepatocellular carcinoma: a case report.

Genes, chromosomes & cancer - 1 Nov 2006

Katoh Hiroto, Shibata Tatsuhiro, Kokubu Akiko, Ojima Hidenori, Kosuge Tomoo, Kanai Yae, Hirohashi Setsuo

Abstract excerpt

Although activated Wnt/beta-catenin pathway is considered to be one of the main driving forces of hepatocarcinogenesis, no somatic mutations of the adenomatous polyposis coli (APC) gene have been found in sporadic hepatocellular carcinoma (HCC) to date. Here we present a case of a sporadic nodule...

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Share to Chromosomes, Human, Pair 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16897741
DOI: 10.1002/gcc.20362

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16897741-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Genetic inactivation of the APC gene contributes to the malignant progression of sporadic hepatocellular carcinoma: a case report.PMID 16897741Read ↗

Somatic mutations of beta-catenin play a crucial role in the tumorigenesis of sporadic hepatoblastoma.Semantic proximity Read ↗

Somatic mutations of the APC gene in sporadic hepatoblastomas.Semantic proximity Read ↗

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Sporadic childhood hepatoblastomas show activation of beta-catenin, mismatch repair defects and p53 mutations.Semantic proximity Read ↗

Loss of heterozygosity of chromosome 8p and 11p in the dysplastic nodule and hepatocellular carcinoma.Semantic proximity Read ↗

Biallelic inactivation of the APC gene in hepatoblastoma.Semantic proximity Read ↗

Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas.Semantic proximity Read ↗

Nuclear accumulation of beta-catenin without an additional somatic mutation in coding region of the APC gene in hepatoblastoma from a familial adenomatous polyposis patient.Semantic proximity Read ↗

Chromosomal Alterations in Hepatocellular Nodules by Comparative Genomic Hybridization: High-Grade Dysplastic Nodules Represent Early Stages of Hepatocellular CarcinomaSemantic proximity Read ↗

Hepatocellular adenoma displaying a HNF1alpha inactivation in a patient with familial adenomatous polyposis coli.Semantic proximity Read ↗

Mutations of the APC gene occur during early stages of gastric adenoma development.Semantic proximity Read ↗

Absence of APC gene mutation in the mutation cluster region in hepatocellular carcinoma.Semantic proximity Read ↗

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