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Article

Endoplasmic reticulum proteins MCTP-1 and ESYT-2 support presynaptic function during sustained activity in Caenorhabditis elegans.

Neuroscience - 11 Sept 2026

Tovilla-Loza Fernando I, Téllez-Arreola José Luis, Martínez-García Ignacio, Pimentel-Domínguez Reinher, Avila Remy, Seidenthal Marius, Gottschalk Alexander, Martínez-Torres Ataúlfo

Abstract excerpt

The presynaptic terminal has a complex molecular organization where numerous proteins are involved in various processes, including vesicle trafficking and neurotransmitter release. Calcium ions play a central role in presynaptic function by triggering neurotransmitter release and synaptic vesicle recycling. Here, we investigated the role of two calcium binding proteins, MCTP-1 and ESYT-2, in the synaptic vesicle...

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Animals, Genetically Modified
Caenorhabditis elegans Proteins
Calcium-Binding Proteins
Endocytosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Endoplasmic Reticulum

Presynaptic Terminals

Synaptic Transmission

Synaptic Vesicles

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Identifiers

PMID: 42336263
DOI: 10.1016/j.neuroscience.2026.06.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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