Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vivo analysis of conserved C. elegans tomosyn domains.

PloS one - 1 Jan 2011

Burdina Anna O, Klosterman Susan M, Shtessel Ludmila, Ahmed Shawn, Richmond Janet E

Abstract excerpt

Neurosecretion is critically dependent on the assembly of a macromolecular complex between the SNARE proteins syntaxin, SNAP-25 and synaptobrevin. Evidence indicates that the binding of tomosyn to syntaxin and SNAP-25 interferes with this assembly, thereby negatively regulating both synaptic transmission and peptide release. Tomosyn has two conserved domains: an N-terminal encompassing multiple WD40 repeats...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Conserved Sequence

Share to Mutant Proteins

Share to Protein Transport

Share to SNARE Proteins

Share to Synapses

Source

Open in PubMed Open full text

Identifiers

PMID: 22022557
DOI: 10.1371/journal.pone.0026185
PMCID: PMC3195084

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vivo analysis of conserved C. elegans tomosyn domains.PMID 22022557Read ↗

Tomosyn negatively regulates CAPS-dependent peptide release at Caenorhabditis elegans synapses.Semantic proximity Read ↗

UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans.Semantic proximity Read ↗

Differential expression and function of synaptotagmin 1 isoforms in Caenorhabditis elegans.Semantic proximity Read ↗

Tomosyn inhibits synaptic vesicle priming in Caenorhabditis elegans.Semantic proximity Read ↗

RSY-1 is a local inhibitor of presynaptic assembly in C. elegans.Semantic proximity Read ↗

Synaptic transmission deficits in Caenorhabditis elegans synaptobrevin mutants.Semantic proximity Read ↗

Loss of the Sec1/Munc18-family proteins VPS-33.2 and VPS-33.1 bypasses a block in endosome maturation in Caenorhabditis elegans.Semantic proximity Read ↗

Open syntaxin overcomes synaptic transmission defects in diverse <i>C. elegans</i> exocytosis mutantsSemantic proximity Read ↗

Synaptic tetraspan vesicle membrane proteins are conserved but not needed for synaptogenesis and neuronal function in Caenorhabditis elegans.Semantic proximity Read ↗

Expression of multiple UNC-13 proteins in the Caenorhabditis elegans nervous system.Semantic proximity Read ↗

SUT-1 enables tau-induced neurotoxicity in C. elegans.Semantic proximity Read ↗

Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.