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Article

Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis.

Development (Cambridge, England) - 1 Sept 2006

Bissonauth Vickram, Roy Sophie, Gravel Mathieu, Guillemette Stéphanie, Charron Jean

Abstract excerpt

Map2k1(-/-) embryos die at mid-gestation from abnormal development and hypovascularization of the placenta. We now show that this phenotype is associated with a decreased labyrinth cell proliferation and an augmented cell apoptosis. Although the activation of MAP2K1 and MAP2K2 is widespread in the labyrinthine region, MAPK1 and MAPK3 activation is restricted to the cells lining the maternal sinuses, suggesting an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16887817
DOI: 10.1242/dev.02526

Genes

MAPK1
MAPK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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